8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Jul 3rd 2026
ReturnsSat, Jul 11th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Mississippi River, Dubuque, Davenport, Hannibal, Alton, St Louis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis… 
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Jul 4th 2026
ReturnsSun, Jul 12th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Cruising the River, Dubuque, Davenport, Hannibal, St Louis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Jul 10th 2026
ReturnsSat, Jul 18th 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Alton, Mississippi River, Hannibal, Mississippi River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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Outside
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Jul 11th 2026
ReturnsSun, Jul 19th 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Mississippi River, Hannibal, Cruising the River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Jul 17th 2026
ReturnsSat, Jul 25th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Mississippi River, Dubuque, Davenport, Hannibal, Alton, St Louis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Outside
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Jul 18th 2026
ReturnsSun, Jul 26th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Cruising the River, Dubuque, Davenport, Hannibal, St Louis (2 Days)
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Outside
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Jul 24th 2026
ReturnsSat, Aug 1st 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Alton, Mississippi River, Hannibal, Mississippi River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Outside
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsSat, Jul 25th 2026
ReturnsSun, Aug 2nd 2026
Nights8
Departing PortSt Louis
Ports of CallSt Louis, Mississippi River, Hannibal, Cruising the River, Muscatine, Dubuque, Winona, Red Wing, Minneapolis/St. Paul
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Outside
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Balcony
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Suite
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8 Night U.S. Rivers Cruise
Cruise LineAmerican Cruise Lines
ShipAmerican Serenade
DepartsFri, Jul 31st 2026
ReturnsSat, Aug 8th 2026
Nights8
Departing PortMinneapolis/St. Paul
Ports of CallMinneapolis/St. Paul, Mississippi River, La Crosse, Mississippi River, Dubuque, Davenport, Hannibal, Alton, St Louis
Coming in 2023 – American SerenadeAmerican Cruise Lines is pleased to announce American Serenade, one of the newest ship in our revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Missis…
Inside Cabin
Call for pricing
Outside
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Balcony
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Suite
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Prices are per person, double occupancy, cruise only and on select sailings. Prices shown are for stateroom categories as noted and are shown in US Dollars. Pricing listed includes taxes and fees. Airfare is not included. Prices and itineraries are based on availability and are subject to change without notice.
